![]() In 1789, by order of the King of Spain, an overland route was laid out to connect the cities of St. The area was claimed by the French as part of La Louisiane, and they ceded it in 1763 to the Spanish after being defeated by Britain in the Seven Years' War. In 1541, Spanish explorer Hernando de Soto may have stood upon the Sikeston Ridge, although some historical references dispute this, believing that he traveled further south than Sikeston. This was the world's largest drainage project, moving more earth than completed during the construction of the Panama Canal. At the beginning of the 20th century, the Little River Drainage District was formed to reclaim the land. The first explorers and settlers came to a region of cypress swamps and forested prairies. ![]() Before the 2010 census, it had been the second-most populous city in the congressional district. It is the principal city of the Sikeston Micropolitan Statistical Area, which consists of all of Scott County, and has a total population of 41,143.Īs of the 2020 census, the city population was 16,291, making it the fourth-most populous city in Missouri's 8th Congressional district behind Cape Girardeau, Rolla, and Farmington, and just ahead of Poplar Bluff which has had a similar population as Sikeston over the last few decades. The city is named after John Sikes, who founded it in 1860. Louis and Memphis, Tennessee and is three hours from Nashville. Route 60, Sikeston is close to the halfway point between St. By way of Interstate 55, Interstate 57, and U.S. ![]() It is situated just north of the " Missouri Bootheel", although many locals consider Sikeston a part of it. Sikeston / ˈ s aɪ k s t ən/ is a city located both in southern Scott County and northern New Madrid County, in the state of Missouri, United States.
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